Beta-thalassemia minor is a beneficial determinant of red blood cell storage lesion
نویسندگان
چکیده
منابع مشابه
Red blood cell storage lesion.
The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell (RBC) transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectivel...
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Patients with heterozygous beta-thalassemia minor have a decreased hematocrit (HCT). Since the HCT is a primary determinant of whole blood viscosity, the known reduction in HCT in beta-thalassemia minor should lead to a measurable reduction of whole blood viscosity. The influence of the relatively lower mean corpuscular volume and consequent higher red blood cell count and beta-thalassemia mino...
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Transfusion of RBCs is often clinically necessary--and life-saving--for anemic patients. RBCs can be stored for up to 42 days between the time of donation and the time of transfusion. For many years, investigators have studied the biochemical changes that occur in RBCs stored before transfusion (the RBC "storage lesion"). More recently, clinical studies have suggested that RBC units stored for ...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2021
ISSN: 1592-8721,0390-6078
DOI: 10.3324/haematol.2020.273946